In vitro trials
The net adsorption capacities of Figure 2 are
determined by different independent laboratories
in the USA (California andMissouri) and by the
University of Utrecht (the Netherlands).When
comparing the net adsorption with other products it
is important to realize that only the net adsorption is
important. This means that the adsorption needs to
be fnal, themycotoxin should stay bound to the binder.
For example: activated charcoal has a total adsorption
of 98%, but 90% is released again, so the net adsorption
is just 8%. Inmany cases only the total adsorption is
given.
In vivo trials
The product has not just been tested in the
laboratory, because effectiveness in a lab is never a
guarantee that it will work adequately in the animal.
Therefore Cobind Bhas been extensively tested in
vivo. More data is available upon request.
The trial shown was carried out with male broilers (Ross
308) using four treatments of eight replicas each. During
the frst fve days all birds received the same starter feed.
The experimental diets were fed from fve to 38 days of
age. Group A was not contaminated with mycotoxins.
Group B (T2-group) and C (T2+binder-group) were
contaminated with 1250 ppb T-2mycotoxin. Results are
shown in Table 3.
T-2 contaminationhad a signifcant negative effect on gain,
feed intake (FI), feed conversion ratio (FCR) and oral lesion
score (0 = no lesions; 3 = severe lesions). The addition of
Cobind B caused a highly signifcant improvement inboth
performance aswell as lesion score (see group B vs. group
C in Table 3). Differences that remainedbetween the
non-contaminated control and the group using CobindB
were not statistically signifcant except for the oral lesion
scores (see groupA vs. group C in Table 3).We can therefore
conclude that the addition of Cobind B supports the birds
in coping with a mycotoxin contamination. This results in
signifcant improvements inbirdperformance.
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a,b,c
)Within each column datawith no common superscript differ signifcanty (P<0,05)
Table 3. Effect of CobindBon technical results by broilers
Treatment
BW(g) BW(g) Gain (g)
Fl (g)
FCR Oral Lesion
5d.
38d.
5-38d.
5-38d.
Score
A. Control
125
a
1879
a
1754
a
3370
a
1.92
a
0.25
a
B. T2
126
a
1563
b
1437
b
3149
b
2.19
b
2.75
c
C. T2+binder
125
a
1772
a
1647
a
3245
a
1.97
a
1.75
b
Inclusion rate
The recommended dosage of Cobind B is
0.5-2 kg/t of fnal feed depending on the extent
of the mycotoxin contamination. The standard
inclusion rate is 1 kg/t.
Mycotoxins can have a major negative impact on
bird performance. It is diffcult to control the quality
of individual rawmaterials. However, adding Cobind
Boffers security that, should a batchof poorer
quality rawmaterial be used, the performance and
healthof the birds are protected.
Advantages of CobindB
•
Broadworking spectrum
•
Highly effective against all common
mycotoxins
•
Extensively tested in vitro and in vivo
•
No adsorptionof other nutrients
•
Relatively low inclusion rate
•
Price competitive
CobindB:
Bound for Success !